Initial episode, 1st recurrence: 125mg po q6h for 10-14 days.
Initial or recurrent episode – severe or fulminant: 500 mg PO q6h
Intra-colonic dose: 500mg in 100mL of NS by rectal enema q6h
Only indication is in the therapy of C. difficile infection
Possibility of accumulation in severe renal dysfunction with severe colonic damage.
Consider checking a vancomycin level in dialysis patients.
No oral absorption.
May increase vancomycin resistant Enterococci colonization in the gut.
Antimicrobial class: Glycopeptide
Pregnancy category: B
Average serum half life: 0 hours
Biliary penetration: None
CSF penetration: None
Lung penetration: None
Urine penetration: None