Vancomycin PO

C difficile risk
Oral Bioavailability


  • Initial episode, 1st recurrence: 125mg po q6h for 10-14 days.

  • Initial or recurrent episode – severe or fulminant: 500 mg PO q6h

  • Intra-colonic dose: 500mg in 100mL of NS by rectal enema q6h

General Information

Only indication is in the therapy of C. difficile infection

Possibility of accumulation in severe renal dysfunction with severe colonic damage.

Consider checking a vancomycin level in dialysis patients.

No oral absorption.

May increase vancomycin resistant Enterococci colonization in the gut.

Antimicrobial class: Glycopeptide

Pregnancy category: B

Average serum half life: 0 hours

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None

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