C difficile risk
Oral Bioavailability


Usual indications 600 mg IV q8h OR 300-450mg PO Q6-8h

Necrotizing SSTI or toxic shock syndrome 900mg IV q8h

General Information

  • Certain anaerobic infections, especially dental infection. Not for intraabdominal infections.

  • Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production by certain organisms.

  • Skin & soft tissue infections involving susceptible MRSA.

  • Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.

None specific.

Monitor for diarrhea.

C. difficile infection

Muscle relaxants, e.g., atracurium, baclofen, diazepam.

St. Johns Wort

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

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