Spectrum Of Activity
Used synergistically in enterococcal endocarditis.
Empiric (in combination) or targeted therapy for suspected or confirmed gram negative infections.
Monitor creatinine at least 3 times/week. Discontinue if any signs of ototoxicity.
Avoid concomitant nephrotoxins
Less common with once daily dosing
Greater toxicity with longer duration and supratherapeutic trough levels
Require audiology testing if prolonged use
Can exacerbate neuromuscular blockade
- Contraindicated in patients with myasthenia gravis
- Loop diuretics (e.g. furosemide)
Non-depolarizing muscle relaxants may be potentiated
Formal audiology assessment if planning to use aminoglycoside for >7d or if symptoms develop.
Inform patient of risk of ototoxicity and to report any symptoms.
Antimicrobial class: Aminoglycoside
Pregnancy category: D
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic