Used synergistically in enterococcal endocarditis.
Empiric (in combination) or targeted therapy for suspected or confirmed gram negative infections.
Monitor creatinine at least 3 times/week. Discontinue if any signs of ototoxicity.
Can exacerbate neuromuscular blockade
Non-depolarizing muscle relaxants may be potentiated
Formal audiology assessment if planning to use aminoglycoside for >7d or if symptoms develop.
Inform patient of risk of ototoxicity and to report any symptoms.
Antimicrobial class: Aminoglycoside
Pregnancy category: D
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic