C difficile risk
Oral Bioavailability


1-2 gm IV q6-8h

CrCl 0-5CrCl 5-9CrCl 10-29CrCl 30-500.5-1 gm IV q24-48h0.5-1 gm IV q12-24h1-2 gm IV q12-24h1-2 gm IV q8-12h

1-2 gm IV after each HD session

General Information

  • Surgical prophylaxis for GI surgery

  • Aspiration pneumonia

  • Mild-moderate intra-abdominal infections

  • Cat/dog/human bites

  • Mild-moderate diabetic foot infections

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • GI upset

  • Diarrhea

  • Abnormal liver enzymes

No significant interactions

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Route of Elimination: Renal (85% unchanged drug in urine)

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