Ampicillin-sulbactam
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Not on Dialysis (Adult)

CrCl 0 - 14

Severe infections or Wt > 80 kg or age <70 yo: 3 g q24h

Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q24h

CrCl 15-29

Severe infections or Wt > 80 kg or age <70 yo: 3 g q12h

Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q12h

CrCl 30-50

Severe infections or Wt > 80 kg or age <70 yo: 3 g q6h

Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q6-8h

CrCl > 50

Usual dosing

Intermittent Dialysis

Severe infections or Wt > 80 kg or age <70 yo: 3 g q24h

Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q24h