In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.
If improving renal function, actual CrCl is likely higher than calculated CrCl.
If worsening renal function, actual CrCl is likely lower than calculated CrCl.
Not on Dialysis (Adult)
Severe infections or Wt > 80 kg or age <70 yo: 3 g q24h
Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q24h
Severe infections or Wt > 80 kg or age <70 yo: 3 g q12h
Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q12h
Severe infections or Wt > 80 kg or age <70 yo: 3 g q6h
Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q6-8h
Usual dosing
Intermittent Dialysis
Severe infections or Wt > 80 kg or age <70 yo: 3 g q24h
Less severe infection or Weight ≤ 80 kg or age 70+ yo: 1.5 g q24h