Guidelines
COVID-19

COVID-19

Definitions

COVID-19 can present as a respiratory infection or with additional non-respiratory symptoms

These symptoms can be present with any viral respiratory infection, including COVID. These symptoms can be present with/without pneumonia.

Including:

  • Fever or feeling feverish/chills (may not be present)

  • Cough

  • Shortness of Breath

  • Sore throat

  • Cold-like symptoms

With influenza the following are more common:

  • Muscle or body aches

  • Headaches

  • Fatigue/lethargy

  • Vomiting and diarrhea (more common in children)

Symptoms may be present with COVID in the absence of ARI.

Including:

  • New olfactory or taste disorder(s)

  • Diarrhea

  • Nausea/vomiting

  • Abdominal pain

  • Fatigue/lethargy

  • Headache

  • Seniors may not have fever, may have delirium, falls, acute functional decline, tachycardia, hypotension

  • Vasculitis like rash

  • Conjunctivitis

Microbiology

Additional Information

The REMAP-CAP Investigators. Interleukin-6 receptor antagonists in critically ill patients with Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2100433.

Salama C, Han J, Yau L et al (2020) Tocilizumab in patients hospitalized with Covid-19 pneumonia. N Engl J Med. https://doi.org/10.1056/NEJMoa2030340

Ontario COVID-19 Drugs and Biologics Clinical Practice Guidelines Working Group Therapeutic Management of Adult Patients with COVID-19. Accessed online August 30, 2021 from: https://covid19-sciencetable.ca/wp-content/uploads/2021/08/CPGSummary_final.pdf

RECOVERY Collaborative Group. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial. Preprint from Feb 11, 2021. DOI: https://doi.org/10.1101/2021.02.11.21249258

Approved: May 2021

Revised:

  • Aug 2021 (updated tocilizumab dosing)
  • Jan 2022 (updated COVID guidance links)
  • Apr 2022 (updated COVID guidance links)
  • May 2022 (added interaction reference)