• Inflammation of gallbladder secondary to gallstones

  • Accounts for 95% of acute cholecystitis

  • Acute necroinflammatory disease of the gallbladder with multifactorial pathogenesis

  • Accounts for approx 5% of acute cholecystitis

  • High morbidity and mortality

  • Often seen in hospitalized or critically ill patients

  • Gangrenous gallbladder presents in 50%

  • Sepsis

  • Gangrenous gallbladder

  • Generalized peritonitis (perforation)

  • Abdominal crepitus (emphysematous cholecystitis)

  • Bowel obstruction (gallstone ileus)


Additional Information

  • Mayumi T., Okamoto K., et al. Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. J. Hepatobiliary Sci. 2018;25:96–100.

  • The Johns Hopkins University (2020) John Hopkins ABX Guide (1.27) [Mobile App] Retrieved from:

  • Antimicrobial Therapy Inc (2020) The Sanford Guide (4.2) [Mobile App] Retrieved from: