Guidelines
Secondary Prophylaxis

Secondary Prophylaxis

Recommendations

Patients currently or recently treated for CDI may require antimicrobial therapy for a concomitant infection (non-CDI)

  • Continue vancomycin at treatment dose for at least 14 days
  • If other antibiotic duration is longer than CDI treatment continue vancomycin at lower dose (125 mg PO q12h) while on antibiotics
  • Consider an additional week of vancomycin after completion of antibiotic course
  • Vancomycin 125 mg PO q12h administered during the course of the systemic antibiotic therapy and for up to 1 week after its completion