Guidelines
Severe CDI Uncomplicated

Severe CDI Uncomplicated

Note

Discontinue the offending antibiotic if possible

Contact Precautions

WBC > 15, or SCr > 1.5 x baseline, or hypoalbuminemia

Initial Episode or First Recurrence

Second or Subsequent Recurrences

Vancomycin 125 mg PO q6h x 14 days followed by taper

Consult

Consider Infectious Diseases Consult:

  • Required if recurrent (first or subsequent recurrence)
  • Required if ongoing antibiotics are needed

Surgical Consult:

  • Low threshold for surgical consultation