Antimicrobials
Acyclovir

Acyclovir

None
Moderate
IV: $$; PO: $

Spectrum of Activity

Dosing

General Information

Therapy for herpesviral infections (HSV and VZV) including encephalitis.

Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.

Follow SCr as appropriate.

Check urine for crystals if AKI suspected.

  • GI upset
  • Phlebitis
  • Increased SCr
  • AKI from crystal nephropathy

Mycophenolate can increase the acyclovir concentration.

May diminish efficacy of zoster or varicella vaccine.

For oral indications valacyclovir is preferred (more bioavailable & more convenient dosing)

Antimicrobial class: Antiviral. Nucleoside analogue.

Pregnancy category: B

Average serum half life: 3 hours, longer if renal dysfunction

CSF penetration: Therapeutic

Urine penetration: Therapeutic