Therapy for herpesviral infections (HSV and VZV) including encephalitis.
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised.
Follow SCr as appropriate.
Check urine for crystals if AKI suspected.
Mycophenolate can increase the acyclovir concentration.
May diminish efficacy of zoster or varicella vaccine.
For oral indications valacyclovir is preferred (more bioavailable & more convenient dosing)
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours, longer if renal dysfunction
CSF penetration: Therapeutic
Urine penetration: Therapeutic