Antimicrobials
Imipenem

Imipenem

Medium
N/A
$35.28

Dosing

General Information

  • Documented infections due to organisms producing inducible β-lactamases or Extended-Spectrum β-lactamases (ESBL) resistant to alternate agents.
  • Empiric Treatment of life-threatening infections where multi-drug resistant organisms suspected (i.e. severe sepsis, neutropenic patient with absolute neutrophil count < 0.5).
  • Therapy of P. aeruginosa infections where other agents cannot be used due to allergy or toxicity.
  • Therapy of documented or suspected infections due to MRSA, Enterococcus spp., Stenotrophomonas maltophilia, Chlamydia spp. and Mycoplasma spp.
  • Treatment of infections due to organisms susceptible to less costly and/or narrower-spectrum agents
  • Treatment of meningitis or other Central Nervous System Infection (Meropenem is only carbapenem with an indication for CNS infection)
  • Immediate and delayed-type allergy
  • GI disturbance
  • Cytopenias, positive Coombs
  • Liver enzyme abnormalities
  • CNS effects including confusional states and seizures
  • May decrease serum concentrations of valproic acid
  • Ganciclovir/valganciclovir - may increase risk of seizures
  • Cyclosporine - may enhance neurotoxic effects of imipenem

IV Administration

  • 500 mg or less: dilute in 100 mL D5W or NS and administer over 30 min.
  • 750 mg or 1000 mg: dilute in 250 mL D5W or NS , infuse over 60 min

Antimicrobial class: Carbapenem

Pregnancy category: C

CSF penetration: Not indicated for CNS infection - use meropenem