Staphylococcus lugdunensis (Gram Positive Organisms)
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Medium
Good (70 to 90%)
$ 0.87/day (PO) $12.00 day (IV)

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and function.

  •  Allergy/rash (immediate or delayed)
  •  Note EBV related rash
  •  Cytopenias
  •  Diarrhea
  •  Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol

Tablets can be crushed and given via NG tube; Liquid also available

Bioavailability:

  • Bioavailability classification based on Amoxicillin component
  • Clavulanic acid bioavailability varies from 30-98%

Available Strengths (IV):

  • 5:1 ratio Amoxicillin/Clavulanate (500 mg/100 mg and 1000 mg/200 mg)
  • 10:1 ratio Amoxicillin/Clavulanate (2000 mg/200 mg)
  • Note:
    • THE 10:1 AND 5:1 PRODUCTS ARE NOT INTERCHANGEABLE
    • Using 2g vial for smaller doses will result in underdosing of clavulanic acid
    • Using 500 mg or 1g vial for larger doses will overdose clavulanic acid, causing potentially severe GI Side effects

Administration:

  • Reconstitute 500 mg vials with 10 mL Sterile water for injection (SWI), 1g and 2g vials with 20 mL SWI. Further dilute 500 mg doses in 50 mL NS, administer over 30 min.
  • 1g and 2g doses should be diluted in 100 mL NS and infused over 30 minutes

Use promptly once reconstituted; once diluted in NS solutions are stable for 60 minutes at room temperature, 4 hrs refrigerated

Open Benefit: No prescribing restrictions

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic