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Amoxicillin-Clavulanate
Renal

Renal

Not On Dialysis

Dose based on amoxicillin component

eGFR 0 - 10

PO: 250-500mg amox component q24h

IV: 1g initially, followed by 500mg q12-24h

Do not use 10:1 (2g) formulation

eGFR 10 - 30

PO: 250-500mg PO amox component q12h

IV: 1g initially, followed by 500mg q12h

Do not use 10:1 (2g) formulation

eGFR 30 - 50

PO: 250-500mg PO amox component q12h

IV: no dose reduction necessary

eGFR > 50

PO: 500mg PO amox component q8h

IV: No dose reduction necessary

Intermittent Dialysis

Dose based on amoxicillin component

PO

  • 250-500mg PO amox component q24h
  • Give after dialysis on dialysis days

IV

  • 1g initial dose followed by 500 mg q24h;
  • Give dose after dialysis on dialysis days OR give supplemental dose of 500 mg at end of dialysis

Do not use 10:1 (2g) formulation