Enterococcus faecalis (Gram Positive Organisms)
Vancomycin IV

Vancomycin IV

None
N/A
$ 5.78/day

Dosing

General Information

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections.

  • Vancomycin peak levels do not correlate with efficacy and are of no value to guide dosage adjustment.
  • Vancomycin trough level and serum creatinine (Pharmacy consult recommended)
  • CBC at least weekly for duration of therapy > 7 days
  • Nephrotoxicity
  • Cytopenias (should have weekly CBC if therapy > 7 days)
  • Rash including Stevens-Johnson Syndrome
  • Red man syndrome (histamine release- slow down infusion)
  • Aminoglycosides may potentiate nephrotoxicity.
  • Careful with concomitant nephrotoxins.

IV Administration

  • Compatible with D5W or NS
  • Maximum concentration for peripheral administration: 5 mg/mL
  • Infusion time:
    • 1000mg or less = 60 min
    • 1001-1500mg (90 min)
    • 1501-2000mg (2 hrs)

Antimicrobial class: Glycopeptide

Pregnancy category: C

Average serum half life: 8 hours (may be > 200h in ESRD)

Biliary penetration: Moderate

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic