Staphylococcus aureus (Gram Positive Organisms)
Linezolid

Linezolid

Restricted

Low
Complete (100%)
$2.62 (PO) $31.06 (IV)

Dosing

General Information

Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia when first line therapies are precluded by allergy, organism resistance or intolerance/adverse drug reaction.

Covers MRSA and VRE.

CBC at least once/week

Visual testing for therapy >3 months or if symptoms develop on therapy.

  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis
  • Myelosuppression (usually with >2weeks therapy)- reversible
  • Peripheral/optic neuropathy with prolonged courses
  • SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome
  • Pharmacist consult recommended to review drug interactions
  • Rifampin decreases linezolid levels

IV Administration: 600 mg premixed bags; infuse over 60 min (Premixed bags are not compatible with pumps used by Community IV Program)

NLPDP Status (PO): Special Authorization required

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic