Staphylococcus aureus (Gram Positive Organisms)
Daptomycin

Daptomycin

Restricted

Low
N/A
$182.50

Dosage

Information générale

Targeted therapy of resistant gram positive infections when use of first line agents precluded by allergy or intolerance

Creatine kinase and creatinine at least weekly (more frequently if renal function changing or unstable)

  • GI side effects common
  • Rash
  • Phlebitis
  • Increased INR
  • Myopathy including rhabdomyolysis
  • Statins and fibrates - Increased myopathy.
  • Monitor creatine kinase or hold while on daptomycin therapy.

IV Administration

  • Dilute in 100 mL NS and administer over 30 min.
  • Concentration range: 2.5-20 mg/mL

Inactivated by pulmonary surfactant : Not indicated for pulmonary infection.

Antimicrobial class: Cyclic Lipopeptide.

Pregnancy category: B

Average serum half life: 9 hours

CSF penetration: Poor

Lung penetration: Poor

Urine penetration: Therapeutic