Staphylococcus aureus (Gram Positive Organisms)
Trimethoprim-Sulfamethoxazole

Trimethoprim-Sulfamethoxazole

Low
Good (70 to 90%)
$0.08 (PO) $85.80 (IV)

Dosing

General Information

  • Urinary tract infections
  • Susceptible MRSA infections
  • Stenotrophomonas infections
  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  •  Gastrointestinal upset common
  •  Bone marrow suppression
  •  Hyperkalemia
  •  Renal failure
  •  Hepatitis
  •  Aseptic meningitis
  •  Stevens Johnson syndrome/toxic epidermal necrolysis
  •  Other rashes
  • ACEi - Increased serum potassium level
  • Increases amantadine levels
  • Decreases cyclosporine
  • Methotrexate - Marrow suppression
  • Increases phenytoin
  • Increases rifampin
  • Increases INR with warfarin

IV Administration

  • Dilute each 5mL amp in 100-125 mL NS or D5W. Administer dose over 60-90 min.
  • May dilute each 5 mL amp in 50-75 mL if fluid restricted but stability may be markedly decreased

Each 5 mL ampoule contains:

  • 80 mg Trimethoprim
  • 400 mg Sulfamethoxazole

Each single strength (SS) tablet contains:

  • 80 mg Trimethoprim
  • 400 mg Sulfamethoxazole

Each double strength (DS) tablet contains:

  • 160 mg Trimethoprim
  • 800 mg Sulfamethoxazole

Tablets may be crushed for NG administration; Liquid formulation is also available.

  • 10mL Oral liquid = 1 single strength (SS) tablet
  • 20mL Oral liquid = 1 double strength (DS) tablet

OPEN BENEFIT (PO): No prescribing restrictions

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic