Trimethoprim-Sulfamethoxazole
Renal

Renal

Not On Dialysis

eGFR 0 - 10

Not recommended.

Consult pharmacy if use is deemed essential.

eGFR 10 - 30

50% of usual dosing

eGFR > 30

Usual dosing

Intermittent Dialysis

PO

1 single strength tablet q12h OR one double strength tablet once daily

IV

2.5-5mg/kg of TMP component q24h

Dose after hemodialysis on dialysis days

Continuous Dialysis

5 mg/kg of TMP component IV q8h

Depends on indication and type of renal replacement therapy

Pharmacist consult recommended

Peritoneal Dialysis

Use is generally not recommended

If necessary some regimens include:

  • PO: 1 single strength tablet q12h
  • IV: 5-10mg/kg of TMP component q24h