Antimicrobials
Clarithromycin

Clarithromycin

Medium
Moderate (40 to 70%)
$0.70/day

Spectrum of Activity

Dosing

General Information

  • CAP
  • Pertussis
  • URTI
  • H. pylorI and mycobacterial infections

Monitor QTc in patients with increased risk

  • Neutropenia
  • GI upset
  • Prolongation of QTc interval
  • Drug interactions

Recommend review of patient medications due to high frequency of significant interactions

  • CYP450 interactions ++
  • Other QTc prolonging agents
  • Statins - increased rhabdo
  • CCBs - hypotension, AKI
  • Colchicine - increased bone marrow toxicity
  • Increased anticonvulsant levels
  • Increased tacrolimus levels

Non-XL Tablets can be crushed for NG administration; Liquid formulation also available.

OPEN BENEFIT: No prescribing restrictions

Antimicrobial class: Macrolide

Pregnancy category: C

Average serum half life: 5 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor