Recommend review of patient medications due to high frequency of significant interactions
CYP450 interactions ++
Other QTc prolonging agents
Statins - increased rhabdo
CCBs - hypotension, AKI
Colchicine - increased bone marrow toxicity
Increased anticonvulsant levels
Increased tacrolimus levels
EH Prescribing Restrictions None
Non-XL Tablets can be crushed for NG administration; Liquid formulation also available
Antimicrobial class: Macrolide
Pregnancy category: C
Average serum half life: 5 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Poor
