eGFR < 50eGFR > 50400mg IV q24h or 200 mg IV q12h
250 PO q12h or 500 mg PO q24h400mg IV q8-12h
500-750mg PO q12h
400mg IV or q24h or 200 mg IV q12h
250 mg PO q12h or 500mg PO q24h
Dose after HD on dialysis days
Peritoneal Dialysis 200 to 400 mg every 12 to 24 hours 400mg IV or q24h or 200 mg IV q12h
500mg PO q24h OR 250 mg PO q12h
Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen and other sites
QTc prolongation
Dysglycemia
Tendinopathy and rupture
GI upset
Rash
Retinal detachment
CNS toxicity including confusion, psychosis
Weakness exacerbation in myasthenia gravis
CYP1A2 inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption
Cyclosporine - Increased levels of cyclosporine
Warfarin - Increased INR
Methadone - Lowered seizure threshold
IV Administration
Premixed bags of 200 mg and 400 mg; Infuse over 60 min
NOTE: premixed bags are incompatible with pumps used in Community IV program
EH Prescribing Restrictions
NONE
Pharmacist review of therapy for IV
Community IV Formulary (Metro Region)
Ciprofloxacin suspension clogs enteral feeding tubes. Crush tablets for administration via tube if required.
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic
