Antimicrobials
Amphotericin - Lipid Associated

Amphotericin - Lipid Associated

Low
N/A
$550-650/day

Spectrum of Activity

Dosing

General Information

Fungicidal therapy of yeast/fungus/mold infection.

Invasive candidiasis, aspergillosis, cryptococcosis.

Visceral/mucocutaneous Leishmaniasis.

Induction therapy for dimorphic fungii (cocci, blasto, histo).

Not for use in urinary tract infection.

  • Renal function
  • K
  • Mg
  • HCO3
  • Liver enzymes
  • CBC

Frequency depends on course, but daily reasonable during initiation

Same toxicities as conventional Amphotericin B but with less frequency.

  • Nephrotoxicity ++
  • Anemia
  • Phlebitis
  • Arachnoiditis
  • Urinary retention
  • Paresthesias

Infusion related symptoms

  • Fever
  • Rigors
  • N/V
  • Headache

Electrolyte abnormalities

  • HypoK and HypoMg
  • Loss of bicarb
  • See additional information

Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.

Increased digoxin toxicity with hypokalemia.

Please specify formulation and patient weight when ordering

IV Administration

Abelcet (Lipid Complex)

  • D5W only (incompatible with NS)
  • Dilute to 1-2 mg/mL
  • Administer over 2 hours

Ambisome (Liposomal)

  • D5W only (incompatible with NS)
  • Dilute to 0.5-2 mg/mL
  • Administer over 1-2 hours

Antimicrobial class: Antifungal. Polyene. Lipid formulations designed to minimize toxicity.

Average serum half life: 150 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor