Substrate and potent inducer of CYP3A4. Also inducer of CYP2B6, 2C8, 2C9, 2C19, 2D6, and p-glycoprotein. Inductive effects typically take 1-2 weeks to reach steady state, and the inductive effects typically resolve 2 weeks after discontinuation of therapy.
REVIEW ALL MEDICATIONS CLOSELY FOR DRUG INTERACTIONS. THIS IS NOT AN ALL INCLUSIVE LIST.
- Amiodarone: amiodarone serum concentration may be significantly decreased
- Amlodipine: amlodipine serum concentrations may be significantly decreased
- Atorvastatin: atorvastatin serum concentrations may be significantly decreased
- Corticosteroids: corticosteroid serum concentrations may be significantly decreased
- Digoxin: digoxin serum concentrations may be significantly decreased by 30-60%
- HIV medication: interactions with several different HIV medications; please review in Lexicomp drug interaction checker
- Fluconazole: fluconazole serum concentrations decreased by 23-56%
- Glimepiride: glimepiride serum concentrations may be significantly decreased
- Glyburide: glyburide serum concentrations may be significantly decreased
- Levothyroxine: levothyroxine serum concentrations may be significantly decreased
- Oral contraceptives: serum concentrations may be significantly decreased
- Phenytoin: phenytoin serum concentrations may be significantly decreased
- Rivaroxaban: avoid combination since rivaroxaban concentrations can be significantly decreased
- Tacrolimus: monitor tacrolimus concentrations because may be significantly decreased
- Voriconazole: combination contraindicated because voriconazole dose increases do not correct the decreased concentrations (93-96% decrease)
- Warfarin: warfarin concentrations may be significantly decreased