Antimicrobials
Pyrazinamide

Pyrazinamide

Low
Moderate

Spectrum of Activity

Dosing

General Information

Active Tuberculosis treatment

Laboratory

  • CBC with diff and CMP at start and periodically during course

Clinical

  • Monitor for hepatotoxicity
  • Malaise
  • Anorexia
  • Nausea
  • Vomiting
  • Arthralgia
  • Myalgia
  • Hepatotoxicity

Cyclosporine, rifampin, multiple additional

Metabolism: Hepatic

Caution in:

  • Alcoholism
  • Diabetes
  • Gout
  • Porphyria
  • Renal impairment

Adapted from the UCLA Health Antimicrobial Stewardship Program