Antimicrobials
Isoniazid

Isoniazid

Spectrum of Activity

Dosing

General Information

Baseline & periodic LFTs

  • Increased LFTs
  • Vasculitis
  • Skin rash
  • Drug-induced lupus erythematosus (DILE)
  • Hemolytic anemia
  • Acetaminophen
  • Alcohol
  • Alprazolam
  • BCG vaccine
  • Carbamazepine
  • Chlorzoxazone
  • Cholera vaccine
  • Corticosteroids (systemic)
  • Cycloserine
  • Dofetilide
  • Ethionamide
  • Fosphenytoin
  • Ketoconazole
  • Levodopa-containing products
  • Midazolam
  • Nimodipine
  • Phenytoin
  • Simvastatin
  • Tacrolimus
  • Theophylline derivatives

Inhibits synthesis of mycolic acids, an essential component of the bacterial cell wall

Administer with pyridoxine 25-50 mg PO daily to decrease risk of INH-associated peripheral neuropathy