Spectrum of Activity


General Information

  • Baseline LFTs
  • Serum creatinine
  • CBC
  • Mental status
  • Hepatotoxicity
  • Immediate & delayed hypersensitivity reactions
  • Dermatologic reactions (SJS, TEN, DRESS)
  • Orange-red discoloration of body secretions
  • Flu-like syndrome
  • Thrombocytopenia
  • Leukopenia
  • Anemia

Strong CYP Inducer - many drug-drug interactions; utilize Clinical Pharmacology or Lexicomp for full list

Prevents RNA transcription by inhibiting bacterial RNA synthesis by binding to the beta subunit of DNA-dependent RNA polymerase

  • Administer on an empty stomach with a glass of water to increase total absorption.
  • May mix contents of capsules with applesauce or jelly.