Cefiderocol
Renal

Renal

Renal adjustment

CrCl >120

May consider 2 g q6h

CrCl 60-119 mL/min

No adjustment required (2 g q8h)

CrCl 30-59

1.5 g IV q8h

CrCl 15-29

1 g IV q8h

CrCl <15 or HD

750 mg IV q12h

CRRT, dose based on effluent flow rate
Flow Rate Dose
< 2 L/hr 1.5 g q12h
2.1 to 3 L/hr 2 g q12h
3.1 to 4 L/hr 1.5 g q8h
> 4.1 L/hr 2 g q8h

Flow rate -- ultrafiltrate flow rate for CVVH, dialysis flow rate for CVVHD, ultrafiltrate flow rate plus dialysis flow rate for CVVHDF