Antimicrobials
Cefiderocol

Cefiderocol

Restricted

N/A
N/A

Spectrum of Activity

Dosing

General Information

  • Reconstitute 1 g vial with 10 mL of NS or D5W
  • Gently shake to dissolve
  • Allow the vial to stand until the foaming generated on the surface has disappeared (typically within 2 minutes)
  • The final volume of the reconstituted solution is ~11.2 mL
  • Withdraw appropriate volume from reconstituted vial and add to 100 mL infusion bag of NS or D5W
  • Complicated urinary tract infections, including pyelonephritis
  • Hospital-acquired and ventilator-associated pneumonia

Tier 4 Protected Antimicrobial

  • May be ordered by an ID physician for the defined use-criteria, if specified. If a non-ID prescriber orders a restricted antimicrobial, Pharmacy will contact the prescriber to notify him or her of this status and to select an alternative antimicrobial. If the restricted antimicrobial is necessary or is a continuation of a home medication, the prescriber must place a consult for an ID specialist to assess the necessity of this antimicrobial. Once the consult has been placed, Pharmacy will dispense the medication. These agents will be monitored by the ASP/Pharmacy and utilization/compliance reported quarterly.

Non-Formulary Antimicrobial

  • Requires approval from Antimicrobial Stewardship Subcommittee Chairpersons, regardless of inpatient or outpatient status. These medications are not stocked in the Pharmacy and require 24-48 hours for approval and procurement of the drug.

Monitor renal function. Observe for signs and symptoms of anaphylaxis during first dose.

  • Diarrhea
  • Infusion site reactions
  • Constipation
  • Increased LFTs
  • Nausea
  • Inhibits cell wall synthesis by inhibiting PBP
  • Acts as a siderophore and binds to extracellular free ferric iron