Antimicrobials
Oxacillin

Oxacillin

Low
N/A

Dosing

General Information

Administration

  • IV push over 10 minutes
  • IV piggyback over 30 minutes

Preparation

  • 1g vial: reconstitute with 10mL SWFI or NS
  • 2g vial: reconstitute with 20mL SWFI or NS
  • 10g vial: reconstitute with 93mL SWFI or NS (concentration 100mg/mL)
  • Shake vial well
  • Further dilute in D5W or NS prior to administration

Diluent

  • NS or D5W

Treatment of susceptible Staphylococcal (MSSA) infections

  • Bacteremia
  • Endocarditis
  • Osteomyelitis
  • SSTIs

Tier 1 Protected Antimicrobial

  • Narrow spectrum, possible transition for discharge, IV to PO
  • Strategy: Total EBM duration set (inpatient and outpatient)
  • Signs/symptoms of anaphylaxis during first dose
  • Periodic CBC, urinalysis, SCr and BUN, and hepatic enzymes
  • Rare hepatotoxicity
  • Acute interstitial nephritis or renal tubular disease
  • Eosinophilia
  • May enhance anticoagulant effect of warfarin
  • May inactivate aminoglycosides if co-administered
  • Decreases mycophenolate concentration
  • Increases methotrexate concentration

Mechanism of action: Penicillin that inhibits cell wall synthesis

Average half-life: 20-30 minutes

  • Neonates (PNA 8-15 days): 1.6 hours

Biliary penetration: Therapeutic, excreted unchanged into bile

Pleural fluid penetration: Therapeutic

CSF penetration: Poor

Urinary penetration: Therapeutic, excreted unchanged into urine