Vancomycin PO

Vancomycin PO


Spectrum of Activity


General Information

Only indication is in the therapy of C. difficile colitis, particularly recurrent or severe disease

Tier 2 Protected Antimicrobial

  • Broad spectrum, but 1st line for common infections, comes with a high risk of poor stewardship if initial workup and follow-up are not in place

Strategies Used:

  1. Appropriate workup initially
  2. Pharmacists audit/de-escalate
  3. Set EBM Duration
  • Possibility of accumulation in severe renal dysfunction.
  • Consider checking a vancomycin level in dialysis patients.

GI side effects

  • Abdominal pain
  • Nausea
  • Vomiting
  • Flatulence

Bile acid sequestrants may diminish therapeutic effect

Antimicrobial class: Glycopeptide

Pregnancy category: B

Average serum half life: 0 hours

Urine penetration: None

Lung penetration: None

CSF penetration: None

Biliary penetration: None

No oral absorption.

May increase vancomycin resistant Enterococci colonization in the gut.