Oseltamivir
Renal

Renal

Not On Dialysis

CrCl <10mL/min

Use not recommended (hasn't been studied)

CrCl >10 to 30mL/min

Treatment: 30mg PO QD Prophylaxis: 30mg PO QOD

CrCl >30 to 60mL/min

Treatment: 30mg PO BID Prophylaxis: 30mg PO QD

CrCl >60mL/min

No dosage adjustment necessary

Intermittent Dialysis

Assumes 3 HD sessions in the 5 day period

Treatment
  • 30mg PO load then 30mg PO after each HD session for 5 day period
  • High-flux HD: 75mg PO after HD sessions for 5 days
Prophylaxis

30mg PO load then 30mg PO after HD session for 2 weeks

Continuous Dialysis

Treatment
  • 30mg PO QD for 5 days or
  • 75mg PO Q48H to provide 5-day duration
Prophylaxis

No data