Antimicrobials
Fluconazole

Fluconazole

None
Excellent

Spectrum of Activity

General Information

Administration

  • IV infusion over 1-2 hours, not to exceed 200mg/hr
  • PO dosing with or without food

Preparation

  • IV solution: 200mg/100mL or 400mg/200mL in NS

Compatibility

  • D5W, NS, or LR
  • Candida infections both mucocutaneous and invasive - i.e. Candidemia.
  • Cryptococcus and Coccidioides infections.
  • Antifungal prophylaxis in immunocompromised.
  • Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement
  • Periodic liver and renal function tests
  • Potassium
  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash
  • Alopecia
  • GI upset
  • Many via CYP450. Suggest review specific patient medications.
  • Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.
  • Risk when combining with other QTc prolonging medications.

Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20-30 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Diflucan