Spectrum of Activity


General Information


  • IV push over 2-4 minutes
  • IV infusion over 30-40 minutes
  • Oral dosing with water 1 hour before or 2 hours after meals


  • IM: reconstitute with SWFI for final concentration 125 or 250mg/mL
  • IV injection: reconstitute with SWFI for final concentration 50 or 100mg/mL
  • IV infusion: reconstitute with SWFI to final concentration of 250mg/mL then further diluted into D5W or NS


  • D5W or NS. Not tested in LR

Treatment of MSSA infections (bacteremia, endocarditis, osteomyelitis, pneumonia, SSTIs)

Tier One

  • Narrow spectrum, possible transition for discharge, IV to PO
  • Strategy: total EBM duration set (inpatient and outpatient)
  • CBC with differential at baseline and weekly after
  • Periodic urinalysis
  • BUN/SCr to monitor for renal injury
  • Hepatic function
  • Allergy (immediate or delayed)
  • Cytopenias
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes
  • Phlebitis at injection site in a peripheral vein

Can increase methotrexate levels.

Decrease mycophenolate levels.

Tetracyclines can diminish cloxacillin activity.

Vitamin K Antagonists anticoagulation effect can be enhanced

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 0.5-1.5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Low-Therapeutic, increases with inflamed meninges

Bone penetration: Therapeutic

Biliary penetration: Moderate