• CAP
• Pertussis
• URTI
• H. pylorI and mycobacterial infections

Tier One

• Narrow spectrum, possible transition for discharge, IV to PO
• Strategy: total EBM duration set (inpatient and outpatient)

Monitor QTc in patients with increased risk

BUN and SCr for renal function/injury

Monitor for extensive diarrhea or bloody diarrhea, test for C. diff. as indicated

• Neutropenia
• GI upset
• Prolongation of QTc interval
• Drug interactions

Recommend review of patient medications due to high frequency of significant interactions

• CYP450 interactions ++
• Other QTc prolonging agents
• Statins - increased rhabdo
• CCBs - hypotension, AKI
• Colchicine - increased bone marrow toxicity
• Increased anticonvulsant levels
• Increased tacrolimus levels

Antimicrobial class: Macrolide

Pregnancy category: C

Average serum half life: 5 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

Biaxin