Antimicrobials
Cephalexin

Cephalexin

Medium
Moderate

Spectrum of Activity

Dosing

General Information

PO administration only

  • If GI distress occurs, take with food
  • Uncomplicated skin and soft tissue infection
  • MSSA infections

Tier 1 Protected Antimicrobial

  • Narrow spectrum, possible transition for discharge, IV to PO
  • Strategy: Total EBM duration set (inpatient and outpatient)

Renal, hepatic and hematologic function periodically

  • Allergy/rash (immediate or delayed)
  • Positive Coombs
  • Cytopenias
  • Eosinophilia
  • Hepatic & renal laboratory abnormalities
  • Increases metformin levels
  • Multivitamins with minerals: decrease absorption of cephalexin
  • Zinc salts: decrease absorption of cephalexin
  • Aminoglycosides: enhanced nephrotoxic effects of AGs

Antimicrobial class: First Generation Cephalosporin.

Average half-life: 0.5-1.2 hours in adults, prolonged with renal impairment

  • Neonates: 5 hours

Post-antibiotic effect: generally <1 hour depending on organism

Pregnancy category: B

Urine penetration: Therapeutic, >90% unchanged drug is excreted into urine

Lung penetration: Moderate

CSF penetration: Poor

Biliary penetration: Moderate