Cefuroxime
Renal

Renal

Not On Dialysis: PO Dosing

CrCl <10mL/min

250mg PO Q24H (preferred)

Alternative: 250-500mg PO Q48H

CrCl 10-30 mL/min

250mg PO Q12H (preferred)

Alternative: 250-500mg PO Q24H

CrCl > 30mL/min

No adjustment necessary

Not On Dialysis: IV Dosing

CrCl <10mL/min

0.75-1.5g IV Q24H

CrCl 10-30mL/min

0.75-1.5g IV Q12H

CrCl > 30mL/min

No adjustment necessary

Augmented renal clearance (urinary CrCl 130mL/min or more)

Extended infusion: 1.5g IV Q6H infused over 3 hours -or- Continuous infusion: 1.5g loading dose followed by 6g IV Q24H infused over 24 hours

Intermittent Dialysis

750-1500mg IV Q24H

250mg PO Q24H

Give dose after HD on dialysis days.

Continuous Dialysis

1.5g IV Q12H

Peritoneal Dialysis

750-1500mg IV Q24H

250mg PO Q24H