Spectrum of Activity


General Information


  • IM deep into large muscle mass
  • Infuse IV over 15-30 minutes
  • IV push over 3-5 minutes
  • Oral: administer with food to improve absorption


  • Duplex containers: squeeze diluent chamber until seal between that and drug powder opens, then shake until dissolved


  • D5W, NS, or LR
  • Community acquired pneumonia with a macrolide
  • Intra-abdominal infection
  • Epiglottitis

Tier 1 Protected Antimicrobial

  • Narrow spectrum, possible transition for discharge, IV to PO
  • Strategy: Total EBM duration set (inpatient and outpatient)
  • Renal, hepatic and hematologic function periodically with prolonged use
  • Prothrombin time in nutritionally-deficient patients, prolonged therapy, renal or hepatic disease
  • Hemolytic anemia and bleeding
  • Allergy (immediate & delayed)
  • Positive Coombs
  • Cytopenias
  • GI upset
  • Diarrhea
  • Abnormal liver enzymes
  • Histamine H2 receptor antagonists, Proton Pump Inhibitors, and Antacids: decrease absorption of oral dose, separate drugs by at least 2 hours
  • Vitamin K Antagonists: enhance anticoagulant effects of warfarin
  • Aminoglycosides: enhanced nephrotoxicity

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor, does cross blood-brain barrier

Biliary penetration: Therapeutic

Cefitin, Zinacef