Antimicrobials
Cefazolin

Cefazolin

Medium
N/A

Dosing

General Information

Preparation

  • Dilute vial with sterile water (SWFI)
  • Dilute further with 5mL SWFI for direct injection -or-
  • Prepare IV in 50-100mL compatible solution (D5W or NS)

Administration

  • IV over 3 to 5 minutes or as an intermittent infusion over 30-60 minutes
  • IM injection deep into large muscle mass

Compatibility

  • D5W, LR, NS

Skin and soft tissue infection (e.g. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and gram negative infections.

Tier 1 Protected Antimicrobial

  • Narrow spectrum, possible transition for discharge, IV to PO
  • Strategy: Total EBM duration set (inpatient and outpatient)
  • INR in warfarin patients, may become elevated
  • Monitor renal, hepatic function, and CBC periodically
  • Allergy (immediate or delayed).
  • Seizure
  • Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities.

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

  • Not recommended unless no other alternatives.

Rifampin - vitamin K deficiency and bleeding events (increased toxicity).

  • Avoid concomitant use when possible.

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic