General Spectrum of Activity
Skin and soft tissue infection (e.g. cellulitis).
Susceptible Staphylococcal, Streptococcal and gram negative infections.
Tier 1 Protected Antimicrobial
Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.
Rifampin - vitamin K deficiency and bleeding events (increased toxicity).
Antimicrobial class: 1st Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic