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Antimicrobials
Aztreonam

Aztreonam

Restricted

Medium
N/A

Spectrum of Activity

General Spectrum of Activity
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Dosing

General Information

Administration

  • All doses > 1g must be IV administration
  • Slow IV push over 3-5 minutes -or- intermittent infusion over 20-60 minutes

Preparation Bolus: reconstitute vial with 6-10mL of SWFI and shake vigorously Infusion: reconstitute vial with 3mL SWFI per gram of Aztreonam and shake vigorously

  • Reconstituted solution should be clear and colorless to light-yellow straw coloring
  • Upon sitting, solution may turn light pink which does not indicate loss of potency
  • Further dilute in D5W or NS to final concentration of 2% or less

Compatibility

  • D5W, LR, NS

Reserved for Metallo-β-lactamases in combination with avibactam.

Nebulized form used in cystic fibrosis patients.

Empiric therapy for febrile neutropenia.

Tier Four

  • Last line option, uncommonly used based upon susceptibility data, may rarely be used for special scenarios
  • Strategies used: ASP Prior Authorization for Non-formulary, Prescriber-based restriction, Outpatient use

Monitor hepatic and renal function periodically

  • Elevated liver enzymes
  • Cytopenias
  • Eosinophilia
  • Phlebitis at injection site
  • Rash/allergy
  • CNS toxicity

No significant interactions.

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate