Administration
Preparation
Compatibility
Tier One
Monitor QTc in patients with increased risk
LFTs and symptoms of hepatitis (malaise, N/V, abdominal colic, fever, yellowing of skin/eyes)
CBC with differential
Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance.
Antimicrobial class: Macrolide
Pregnancy category: B
Average serum half life: 68 hours
Urine penetration: Poor
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic
Zithromax
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.