Antimicrobials
Ampicillin

Ampicillin

Low
N/A

Dosing

General Information

Administration

  • IM to be injected deep into large muscle mass
  • Direct IV bolus administered over 3-5 minutes (125-500mg doses) or over 10-15 minutes (1-2g doses)
  • Infusion: rapid infusions may cause seizures, adjust the rate so that total dose will be administered before admixture stability expires

Preparation IM:

  • prepare and use within 1 hour. Reconstitute vial with SWFI or bacteriostatic water to final concentration of 125 mg/mL or 250 mg/mL

Intravenous:

  • Reconstitute 125, 250, and 500mg vials in 5mL SWFI or bacteriostatic water
  • Reconstitute 1g vial with 7.4mL and 2g vial with 14.8mL SWFI or bacteriostatic water
  • Further dilute in NS to maximum concentration of 30mg/mL (i.e. 500mg in 50mL NS, 1g in 50mL NS, and 2g in 100mL NS)

Compatibility

  • NS

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Tier 1 Protected Antimicrobial

  • Narrow spectrum, possible transition for discharge, IV to PO
  • Strategy: Total EBM duration set (inpatient and outpatient)

Monitor renal, hepatic and hematologic function periodically with prolonged therapy

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, positive Coombs.

Increased risk of rash with allopurinol.

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic