General Spectrum of Activity
Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity.
Induction therapy for dimorphic fungii (cocci, blasto, histo).
Frequency depends on course, but daily reasonable during initiation
Infusion related symptoms
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Increased digoxin toxicity with hypokalemia.
Antimicrobial class: Antifungal. Polyene
Pregnancy category: B
Average serum half life: 24 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor in adults, high inter-patient variability in preterm neonates.
Premedication with NSAIDs/acetaminophen, diphenhydramine or hydrocortisone are used. Meperidine may be used for rigors.
Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) of NS before and after infusion, as well as K and Mg supplementation PRN.