General Spectrum of Activity
Prophylaxis/treatment of bite wounds.
Polymicrobial infections of the respiratory tract or abdomen.
Skin and soft tissue infections.
Tier 1 Protected Antimicrobial
Narrow spectrum, possible transition for discharge, IV to PO
Strategy: Total EBM duration set (inpatient and outpatient)
For prolonged therapy, monitor liver enzymes and function.
Allergy/rash (immediate or delayed)
Note EBV related rash
Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.
Increased risk of rash with allopurinol
Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1 hour
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Biliary penetration: Therapeutic