Utilize the Severe Sepsis/Septic Shock guidelines
Dose recommendations are based on patients with normal renal function. Refer to drug monograph for dosing in renal impairment
These guidelines may not be appropriate for patients with a history of multi-drug resistant organisms. Consider Infectious Disease consultation
Antibiotic selection should be guided by cultures where available; empiric choices in this guideline are based on local susceptibilities
Enterococcus isolated from mixed cultures in mild-moderate infections are of unclear significance and typically do not require targeted therapy
Yeast, if isolated, should be treated
Community onset or hospitalized < 48 hours
Community onset or hospitalized < 48 hours
Hospitalized > 48 hours or post-operative
These recommendations are meant to guide empiric therapeutic decision making and are not meant to replace sound clinical decision making. Definitive therapy should be based on culture and susceptibility reports
Kyle D. Massey, PharmD
Rebekah Gass, MD
Guidelines
