Dose recommendations are based on patients with normal renal function. Refer to dosing in renal impairment
These guidelines may not be appropriate for patients with a history of multi-drug resistant organisms. Consider infectious disease consultation
Empiric antibiotics for non-CDI infectious diarrhea minimally effects duration of illness and increase risk of side effects and antibiotic resistance
Severe Disease:
High-Risk for Severe Disease:
Radiographic diagnosis of colitis alone is not an indication for systemic antibiotics
Viral etiologies are the most common causes of gastroenteritis and warrant supportive care only
Last Updated: February, 2021
These recommendations are meant to guide empiric therapeutic decision making and should not replace sound clinical decision making. Definitive therapy should be based on culture and susceptibility reports
Shane AL, Mody RK, Crump JA, et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clinical infectious Diseases 2017: 65: 12 PMID: 29053792