Restricted
Renal Function:
Hold therapy for any of the following:
Transaminase elevations
Contains cyclodextrin vehicle, caution in CrCl <30
Remdesivir is an inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase, which is essential for viral replication.
Remdesivir is an adenosine nucleotide prodrug that is metabolized to pharmacologically active nucleoside triphosphate metabolite. Remdesivir triphosphate (RDV-TP) acts as an analog of adenosine triphosphate (ATP) and competes with high selectivity (3.65-fold) over the natural ATP substrate for incorporation into nascent RNA chains by the SARS-CoV-2 RNA polymerase, which results in delayed chain termination during replication of the viral RNA.