Usual Dose: 2g q8h
CrCl 31-50: 2g q12h
CrCl 10-30: 2g q24h
CrCl <10: 1g q24h
HD Supplement: Give recommended maintenance dose after hemodialysis on dialysis days (CrCl <10 mL/min)
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.
Allergy (immediate and delayed).
Note potential cross-reactivity with aztreonam based on side chain.
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic
Biliary penetration: Moderate
