Antimicrobials
Ceftazidime

Ceftazidime

C difficile risk
High
Oral Bioavailability
N/A

Dosing

Usual Dose: 2g q8h

CrCl 31-50: 2g q12h

CrCl 10-30: 2g q24h

CrCl <10: 1g q24h

HD Supplement: Give recommended maintenance dose after hemodialysis on dialysis days (CrCl <10 mL/min)

General Information

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins.

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate