Antimicrobials
Azithromycin

Azithromycin

Medium
Moderate

Spectrum of Activity

Dosing

General Information

Monitor QTc in patients with increased risk

  • Community-acquired pneumonia in combination with a β-lactam
  • Pertussis
  • Bacterial Upper respiratory tract infections
  • Chlamydial infections
  • Non-tuberculosis mycobacterial infections

Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.

Prolonged half life may contribute to macrolide resistance.

  • Other drugs that prolong QTc
  • Increases cyclosporine levels
  • May increase digoxin levels
  • Statins increased risk of rhabdomyolysis

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing - e.g. Salmonella species.

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 68 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic