Antimicrobials
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

C difficile risk
Medium
Oral Bioavailability
Excellent

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and function.

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

  •  Diarrhea

  •  Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic